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Wheat germ

Wheat germ is the embryo of the wheat kernel. It is separated from wheat being milled for flour. Wheat germ is sodium and cholesterol free, and dense in nutrients.

It is rich in vitamin E, magnesium, pantothenic acid, phosphorus, thiamine, and zinc. It is also a source of coenzyme Q10 (ubiquinone) and PABA (para-aminobenzoic acid). Two tablespoons of wheat germ contains 65 calories, 6 grams protein, 2 grams of unsaturated fat, and 2 grams of fiber.

General use

Wheat germ is a food source, and is part of the breads and cereals food group. Its high vitamin and mineral content make it an extremely nutritious food. Wheat germ contains the following nutrients.

• Vitamin E. One cup of wheat germ contains 19.5 mg of vitamin E, and one tablespoon of wheat germ oil is packed with 26.2 mg of vitamin E. Vitamin E is an antioxidant, which is thought to protect the immune system.
• Magnesium. Magnesium assists the body in producing and transferring energy, and helps to maintain heart, bone, muscle, and circulatory system health.
• Pantothenic acid. The panthothenic acid in wheat germ helps the body process and use energy from food, and metabolizes cholesterol and fatty acids. There is approximately 1.24 mg of pantothenic acid, also called vitamin B5, in 0.5 cup wheat germ. The U. S. recommended daily allowance (RDA) of pantothenic acid is 5 mg/day.
• Phosphorus. A quarter cup serving of wheat germ contains 232 mg of phosphorus. Phosphorus helps build bones and teeth and assists in metabolism. Adults should consume approximately 700 mg of the mineral daily.
• Thiamine. Thiamine, one of the B complex vitamins, is essential to normal growth, and to building healthy skin, muscle, bones, and hair. It also promotes normal functioning of the nervous system, and helps the body to metabolize alcohol. One cup of wheat germ contains 1.08 mg of thiamine, and the RDAs for men and women are 1.2 mg and 1.1 mg, respectively.
• growth, immune system function, and hormone production.
• Coenzyme Q10. Coenzyme Q10, or ubiquinone, is an antioxidant that assists cells in transferring energy and oxygen.
• Para-aminobenzoic acid (PABA). PABA helps to maintain the balance of intestinal flora, or bacteria.

Wheat germ is also high in fiber, and contains approximately 1 gram of fiber per tablespoon. A diet high in fiber can be useful in regulating bowel function (i.e., reducing constipation), and may be recommended for patients at risk for colon disease, heart disease, and diabetes.

Preparations

Wheat germ is used extensively in animal feeds, but for human consumption, wheat germ cereals and wheat germ oil are the two most popular preparations of the grain. Both are available in most grocery and health food stores.

A jar of vacuum-packed wheat germ can be safely stored up to one year unopened. Opened jars should be refrigerated, where they can be stored up to nine months if stored properly and tightly sealed.

To increase fiber and nutrients in bread and cereal recipes, wheat germ may be used to replace 0.5–1 cup of regular flour.

Precautions

Because wheat germ contains fat, proper cold storage is necessary to prevent spoilage.

Side effects

There are no known side effects to wheat germ consumption at normal dietary levels.

Wigmore diet

The Wigmore diet is named for its creator, Ann Wigmore. She devised a nutritional system called the Living Foods Program, based on a combination of wheatgrass juice, live sprouts, and fresh raw foods. It is thought that this dietary regimen, which is sometimes called raw nutrition, detoxifies and rebuilds the body.

Persons following the Wigmore diet also avoid using denatured processed commercial foods or anything containing chemicals, especially pesticides. Although the Wigmore diet is essentially a vegetarian diet, its distinctive feature is its emphasis on eating foods in their uncooked state.

Origins

The Wigmore diet was developed during the 1960s by Ann Wigmore, a woman who was born in Eastern Europe in 1909 and emigrated to the United States after World War I. She credited her grandmother with teaching her natural healing methods.


She did not, however, use this folk wisdom immediately but returned to it after years of ill health that included colitis, headaches, and arthritis. When she finally learned that she had cancer, she returned to her grandmother’s healing methods in order to regain her health.

After testing the results of a diet based on sprouts and wheat grass juice in her own life, she wanted others to benefit from what she had learned. Ann Wigmore founded the Hippocrates Health Institute in Boston in 1963, which still teaches her methods of self-healing through a live-foods diet.

Although Ann Wigmore died in a fire in 1993, her diet still attracts new followers. In recent years, the Hippocrates Institute has opened branches in southern California and Florida.

Benefits

The Wigmore diet is based on the assumption that the high levels of living enzymes in fresh raw foods, particularly wheat grass juice and fresh sprouts, provide the body with substances needed to detoxify and regenerate it.

In addition to increased vitality and a strengthened immune system, the Wigmore regimen is thought to help individuals overcome some serious diseases, including arthritis, digestive tract problems, allergies, and even cancer.

Description

Sprouts

Perhaps the essence of what she taught could best be described by Ann Wigmore herself: “Live foods nutrition is super nutrition because it recognizes and appreciates the differences between raw and cooked foods and between natural and synthetic nutrients.

In the conventional nutrition-school curriculum there is little room for a discussion of either the value of enzymes and life forces in foods, or the merits of live (raw) versus cooked foods. Yet the difference, when translated into health terms, is the difference between being vitally healthy and alive, and just breathing.”

The Wigmore diet classifies foods into four major groups: living foods, which include sprout mixtures, sunflower and buckwheat baby greens, living sauerkraut, and the fresh juices of wheat grass and barley; raw foods, which include fresh organic vegetables and ripe fruit, spices, herbs, and raw nuts; whole cooked foods, which include steamed or boiled vegetables, cooked whole grains, and baked root vegetables; and processed fast foods, which include all forms of “junk foods.” People following the Wigmore diet believe that most human diseases are caused when a person’s diet contains mostly foods in the last two groups.

Practitioners of the Wigmore diet encourage people to think of enzyme and oxygen levels as “bank accounts.” The more oxygen and enzymes that can be stored in the cells, the healthier one feels. It has been shown that eating certain foods will maintain enzymes and oxygen at optimal preferred levels.

Other notable features of the Wigmore diet include its emphasis on wheat grass as a “living food medicine” and food combining as a key to good digestion. Wheat grass has been credited with more healings than any other factor in the kegiatan because it is supposed to be rich in over 90 enzymes and minerals that are needed to build up the blood and immune system.

wheatgrass juice

People following the Wigmore diet are encouraged to drink at least two 2-ounce servings of wheat grass juice every day. In addition, wheat grass enemas of 4–8 ounces can be taken “as often as possible” for best results during the detoxification process.

Food combining in the Wigmore diet is based on the assumption that certain food combinations cause stomach cramps, indigestion, bad breath, intestinal gas,or lowered energy levels.

Foods are divided into nine groups: proteins (poultry, fish, dairy products, miso, and yeast); pre-digested proteins (nuts and seeds); starches; vegetables; acid fruits (citrus fruits and sour fruits); subacid fruits (apples, apricots, most berries, and peaches); sweet fruits (bananas, dates, and all dried fruits); melons; and neutral foods (avocados and lemons). Melons are to be eaten alone. While meals made up of foods from any one category are a good combination, for example, fruit and starch are a bad combination.

Another important point in the Wigmore diet is drinking water. Tap water is considered unsuitable, and some form of filter should be used. Distilled water or spring water are preferred.

Preparations

Preparations for the Wigmore diet include a gradual departure from less healthy foods; cleansing the digestive tract with aloe vera or similar products; and encouraging good digestion by eating food at room temperature as often as possible and eating raw or living foods before any cooked foods.

It is thought that the cooked foods hold up the digestion of raw and living foods, causing intestinal gas. Ann Wigmore’s The Sprouting Book discusses the proper preparation of the sprouts that play such a prominent role in her diet.

Precautions

Like all natural therapies, the Wigmore diet will be more effective if environmental as well as nutritional pollution of all types is avoided, and if a generally healthy lifestyle is followed. Such spiritual practices as meditation, visualization, and joining or starting a Living Foods support group are considered important features of a healthy lifestyle.

Side effects

Practitioners of the Wigmore diet warn people to expect certain side effects from detoxification, which is considered a key principle in the Living Foods lifestyle. The diet is believed to clear toxins from the body that have accumulated over years of poor nutritional habits. These toxins are released into the bloodstream and lymphatic system for eventual excretion.

During the detoxification process, the dieter may feel less energetic and uncomfortable in their body. The kegiatan recommends daily non-strenuous exercise, high fiber intake to cleanse the colon, daily dry skin brushing over the entire body, and the use of spirulina (blue-green algae) products to ease the side effects of the detoxification process.

As the Wigmore diet is a purely organic regimen, and avoids the use of medications and all chemicals, the risk of other side effects is minimal. Nevertheless, some individuals will be unable to tolerate this diet, and others may be allergic to the foods that are prescribed.

Research and general acceptance

As with many holistic therapies, the Wigmore diet is met with skepticism from allopathic physicians. On the other hand, there are many clinical cases and testimonials consistent with Ann Wigmore’s predicted benefits.

Wild oat

Wild oat (Avena sativa) is a member of the grass family native to Scotland. There are approximately 25 varieties of the oat plants, and oat is now grown throughout the world.

Avena sativa is the species that is used in herbal remedies. The mature seed of the oat plant is used as a cereal grain. However, much of the plant is used to maintain good health and to remedy disease conditions.

Before maturity oat seeds are in a liquid phase, and they are collected for use in tonics that treat nervous conditions. Wild oat is usually in this stage for two weeks during August.


The seeds mature in the late summer and early fall. If harvested then, the seeds are rolled or ground into oatmeal. If the seeds aren’t harvested at that time, they are referred to as groats.

Once the seeds are harvested, the straw from the plant can be cut up and brewed as oatstraw tea. And the husks surrounding the seeds are used as oat bran.

The only part of this grain that is not used in alternative medicine is the root.

Wild oat is also known as oat, groats, oatstraw, and straw.

General use

Avena sativa is Latin for wild oat, a name that does not provide the complete picture of this grain’s use in alternative and conventional medicine. The old saying “sowing your wild oats” is based on the observation that stallions given wild oat experienced greater sex drives.

wild oat ilustration

Wild oat was thought to have the same effect on men, although that has never been scientifically proven. Nevertheless, dietary supplements containing wild oats are still advertised and sold as boosting the male sex drive.

Wild oat may not be an aphrodisiac or a means of promoting fertility, but the grain has numerous other health benefits.

In the past, people recovering from illnesses ate oatmeal because it was easily digested. Doctors advised overworked people to drink a beverage consisting of wine and oats. The drink was said to restore nervous energy. Oatmeal also served as a treatment for skin conditions.

In contemporary times, oatmeal is acknowledged as a rich source of bran and fiber. The grain is associated with treating high cholesterol . Whole oat products with at least 0.02 oz (0.75 g) of soluble fiber in each serving can reduce the risk of heart disease.

The U.S. Food and Drug Administration allowed manufacturers to make that statement, and add that the fiber product must be part of a diet that is low in cholesterol and saturated fat. A study published in the summer of 2002 reported that oat cereal is superior to wheat cereal in lowering LDL cholesterol levels in adult males.

A new use for the beta-glucans (complex carbohydrates) contained in oats is in the manufacture of functional foods for the management of Type 2 (adult-onset) diabetes. Functional foods are a relatively recent category of foods.

They are not currently defined by any government regulatory body, but are commonly understood to be any potentially healthful food or food ingredient that may provide health benefits beyond the traditional nutrients it contains. Functional foods are sometimes called nutraceuticals.

Oat fiber is also used as a substrate, or growing medium, for Lactobacillus and other bacteria that are introduced into the digestive tract of patients suffering from severe infections of the pancreas.

The “good” bacteria in the intestines help the body to fight off infections elsewhere in the digestive system. The oat fiber provides the bacteria with nourishment without causing any side effects to the patient.

Furthermore, pregnant women can benefit from the calcium and other trace nutrients found in oat straw.

Wild oat is recognized as a natural antidepressant and a mild sedative. It acts like a tonic to the nervous system, providing both nourishment and balance. Oat tea or an oat Bach flower remedy is used as a nervine (preparation given to calm the nerves).

In these capacities, wild oat can be used to treat conditions including headaches, depression, tension, insomnia, anxiety, and feelings of sadness. Wild oat is also a remedy for nerve pain and chronic fatigue.

Oatstraw can be used to ease emotional anxieties and to treat skin conditions such as rashes, psoriasis, burns, eczema, warts, and insect bites.

An oatmeal pack may be used to treat skin conditions. The oatmeal facial is a popular treatment for promoting smoother skin because the textured oat sloughs off dead skin when used as a mask or scrub. An oatstraw bath can provide more relief for skin conditions and neuralgia.

Wild oat is also believed to help with nicotine withdrawal, a remedy recommended by German doctors. The wild oat extract is said to be effective when used for this purpose, and oat cereal is also said to be helpful.

Preparations

Wild oat is available in various forms and is used in various alternative medicine traditions such as homeopathy. Commercial preparations include oatstraw tea, tincture, and the wild oat Bach flower remedy (a liquid concentrate called a stock). The packaged oatmeal sold in the grocery store can also be used for treatments.

Wild oat tea, which is also known as an infusion, is made by pouring 1 c (240 ml) of boiling water over 1–3 tsp (1.5–3 g) of the dried straw. The mixture is steeped for 10–15 minutes and then strained. Wild oat tea should be drunk three times a day.

When wild oat tincture is used, the dosage is 1 oz (1 mL) taken three times a day.

Wild oat can be combined with skullcap and mugwort to provide relief from depression and to improve sleep.

A flower remedy

Flower remedies are liquid concentrates made by soaking flowers in spring water. Also known as flower essences, 38 remedies were developed by homeopathic physician Edward Bach during the 1930s. Bach’s wild oat remedy is taken to resolve conditions such as career anxiety and uneasiness about a lack of direction or commitment.

The daily dosage of the Bach wild oat flower remedy is 2–4 drops (1/8–1/4 ml) taken four times each day. The drops can be placed under the tongue or added to a glass of water. Another remedy is to add some stock to the bath water.

Oat baths

An oatstraw bath can provide relief for irritated skin and neuralgia. A bath is prepared by boiling 1 lb (500 g) of shredded oatstraw in 2 qt (0.95 L) of water. After boiling for 20 minutes, this mixture is strained and used in the bath. Another option is to place cooked rolled oats in a bag and the bag is put in the bath.

Precautions

Wild oat has not been associated with any health risks when taken in proper dosages, according to Physician’s Desk Reference for Herbal Medicines, the 1998 book based on the findings of Germany’s Commission E. The commission is the German counterpart of the U.S. Food and Drug Administration (FDA). The European group’s findings about herbal remedies were published in a 1997 monograph.

However, people diagnosed with gluten sensitivity ( celiac disease) should consult with a doctor or health practitioner to determine if they can safely take wild oat internally.

Side effects

There are no known side effects associated with designated dosages of wild oat.

Interactions

There are no known interactions associated with the use of wild oat and other medications or herbs.

Vitamin K

Vitamin K originates from the German term koajulation. It is also known as antihemorrhagic factor, and is one of the four fat-soluble vitamins necessary for good health.

The others are vitamins A, D, and E. The primary and best-known purpose of vitamin K is support of the process of blood clotting. Prothrombin and other clotting factors are dependent on vitamin K for production.

It also plays a role in bone health, and may help to prevent osteoporosis. Appropriate growth and development are supported by adequate vitamin K.


There are several forms of the vitamin:

• K₁ or phylloquinone; also known as phytonadione
• K₂, a family of substances called menaquinones
• K₃ or menadione, a synthetic form of this vitamin

General use

The Required Daily Amount (RDA) of vitamin K is 5 micrograms (mcg) for infants less than six months old, 10 mcg for babies six months to one year old, 15 mcg for children aged one to three years, 20 mcg for those aged four to six years, and 30 mcg for those seven to ten years old.

Males require 45 mcg from 11–14 years, 65 mcg from 15–18 years, 70 mcg from 19–24 years, and 80 mcg after the age of 24 years. Females need 45 mcg from 11–14 years, 55 mcg from 15–18 years, 60 mcg from 19–24 years, and 65 mcg after the age of 24, and for pregnant or lactating women. These values are based on an estimate of 1 mcg of vitamin K per kilogram of body weight.

The most common use of vitamin K is to supplement babies at birth, thus preventing hemorrhagic disease of the newborn. Routine administration of vitamin K to newborns is, however, being questioned by practitioners of evidence-based nursing.

In 2003 the American Academy of Pediatrics (AAP) restated that prevention of bleeding from early vitamin K deficiency by administration of the vitamin is accepted practice. The AAP also noted that a possible link between supplemental vitamin K and early childhood cancer has not been proven as of 2003.

Others who may benefit from supplemental vitamin K include those taking medications that interact with it or deplete the supply. It also appears to have some effectiveness in preventing osteoporosis, but some studies done involved patients using a high dietary intake of the vitamin rather than supplements.

Source of vitamin K

In 2003, however, a group of Japanese researchers reported that supplemental doses of vitamin K2 given together with vitamin D3 appeared to reduce bone turnover and sustain bone density in postmenopausal women with mild osteoporosis.

People taking warfarin, a vitamin K antagonist, are able to use the vitamin as an antidote if the serum level of warfarin is too high, increasing the risk of hemorrhage. Vitamin K taken by mouth appears to be more effective than intramuscular injections of the vitamin when it is used to counteract the effects of warfarin.

Vitamin K is also used to treat bleeding from the esophagus and other complications of cirrhosis, a disease of the liver.

Some women find that supplemental vitamin K relieves the symptoms of morning sickness during pregnancy. This treatment is even more effective if vitamin K is taken together with vitamin C.

Topical formulations of vitamin K are sometimes touted as being able to reduce spider veins on the face and legs.

The creams are quite expensive and the efficacy is questionable at best. However, recent clinical studies have shown that topical applications of vitamin K given to patients following laser treatments on the face are effective in minimizing bruising from the procedure.

More recently, researchers have been studying vitamin K intensively for its potential anticancer effects. Vitamin K₃ in particular may be useful as an adjuvant treatment for ovarian cancer.

Preparations

Natural sources

Dark green leafy vegetables are among the best food sources of vitamin K in the form of K₁. Seaweed is packed with it, and beef liver, cauliflower, eggs, and strawberries are rich sources as well.

Vitamin K is fairly heat-stable, but gentle cooking preserves the content of other nutrients that are prone to breaking down when heated. Some of the supply for the body is synthesized as vitamin K₂ by the good bacteria in the intestines.

Supplemental sources

Vitamin K is not normally included in daily multivitamins, as deficiency is rare. Oral, topical, and injectable forms are available, but should not be used except under the supervision of a health care provider.

Injectable forms are by prescription only. Supplements are generally given in the form of phytonadione since it is the most effective form and has a lower risk of toxicity than other types. Synthetic forms of vitamin K are also available for supplemental use.

Deficiency

Deficiency of vitamin K is uncommon in the general population but is of particular concern in neonates, who are born with low levels of vitamin K.

Hemorrhagic disease of the newborn can affect infants who do not receive some form of vitamin K at birth. Affected babies tend to have prolonged and excessive bleeding following circumcision or blood draws. In the most serious cases, bleeding into the brain may occur.

Most commonly an injection of vitamin K is given in the nursery following birth, but a series of oral doses is also occasionally used. The primary sign of a deficiency at any age is bleeding, and poor growth may also be observed in children.

Chronically low levels of vitamin K are correlated with higher risk of hip fracture in older men and women. A study done in 2003 reported that the current recommended dietary intake for vitamin K in adults may not be adequate for older women.

Vitamin K Deficiencies

Risk factors for deficiency

Vitamin K deficiency is unusual, but may occur in certain populations, including those on the medications mentioned in interactions, alcoholics, and people with diseases of the gastrointestinal tract that impair absorption. Conditions that may be problematic include Crohn’s disease, chronic diarrhea, sprue, and ulcerative colitis.

Anything that impairs fat absorption also risks decreasing the absorption of the fat-soluble vitamins. Long term use of broad spectrum antibiotics destroys the bacteria in the intestinal tract that are necessary for the body’s production of vitamin K.

Precautions

Allergic reactions to vitamin K supplements can occur, although they are rare. Symptoms may include flushed skin, nausea, rash, and itching. Medical attention should be sought if any of these symptoms occur.

Infants receiving vitamin K injections occasionally suffer hemolytic anemia or high bilirubin levels, noticeable from the yellow cast of the skin. Emergency medical treatment is needed for these babies. Liver and brain impairment are possible in severe cases.

Certain types of liver problems necessitate very cautious use of some forms of vitamin K. Menadiol sodium diphosphate, a synthetic form also known as vitamin K₄, may cause problems in people with biliary fistula or obstructive jaundice. A particular metabolic disease called G6-PD deficiency also calls for careful use of vitamin K₄.

The expertise of a health care professional is called for under these circumstances. Sheldon Saul Hendler, MD, PhD, advises there is no reason to supplement with more than 100 mcg daily except in cases of frank vitamin K deficiency.

Side effects

Oral forms of vitamin K₄ may occasionally irritate the gastrointestinal tract. High doses greater than 500 mcg daily have been reported to cause some allergic-type reactions, such as skin rashes, itching, and flushing.

Interactions

There are numerous medications that can interfere with the proper absorption or function of vitamin K. The long-term use of antacids may decrease the efficacy of the vitamin, as can certain anticoagulants. Warfarin is an anticoagulant that antagonizes vitamin K. Efficacy of the vitamin is also decreased by dactinomycin and sucralfate.

Absorption is decreased by cholestyramine and colestipol, which are drugs used to lower blood cholesterol levels. Other drugs that may cause a deficiency include long-term use of mineral oil, quinidine, and sulfa drugs. Primaquine increases the risk of side effects from taking supplements.

Other types of prescription medications that may cause vitamin K depletion include anticonvulsants (drugs to prevent seizures), including valproic acid; macrolide, aminoglycoside, cephalosporin, and fluoroquinolone antibiotics; phenobarbital; and dapsone (used to treat leprosy and skin infections).

Vitamin E

Vitamin E is an antioxidant responsible for proper functioning of the immune system and for maintaining healthy eyes and skin.

It is actually a group of fat soluble compounds known as tocopherols (i.e., alpha tocopherol and gamma tocopherol). Gamma tocopherol accounts for approximately 75% of dietary vitamin E. Vitamin E rich foods include nuts, cereals, beans, eggs, cold-pressed oils, and assorted fruits and vegetables.

Because vitamin E is a fat soluble vitamin, it requires the presence of fat for proper absorption. Daily dietary intake of the recommended daily allowance (RDA) of vitamin E is recommended for optimum health.


Vitamin E is absorbed by the gastrointestinal system and stored in tissues and organs throughout the body. Certain health conditions may cause vitamin E depletion, including liver disease, celiac disease, and cystic fibrosis.

Patients with end-stage renal disease (kidney failure) who are undergoing chronic dialysis treatment may be at risk for vitamin E deficiency. These patients frequently receive intravenous infusions of iron supplements, which can act against vitamin E.

Vitamin E deficiency can cause fatigue, concentration problems, weakened immune system, anemia, and low thyroid levels. It may also cause vision problems and irritability. Low serum (or blood) levels of vitamin E have also been linked to major depression.

General use

Vitamin E is necessary for optimal immune system functioning, healthy eyes, and cell protection throughout the body. It has also been linked to the prevention of a number of diseases.

The therapeutic benefits of vitamin E include:

• Cancer prevention and treatment. Vitamin E is a known antioxidant, and has been associated with a reduced risk of gastrointestinal, cervical, prostate, lung, and possibly breast cancer. In addition to its role as a cancer preventive, vitamin E is being studied as a cancer treatment. It has been shown to inhibit the growth of prostate tumors and to induce apoptosis (cell self-destruction) in cancer cells. Vitamin E is also being investigated as an adjunctive treatment for cancer patients undergoing radiation therapy; it is thought that high doses of dietary antioxidants may increase the efficacy of the radiation treatment while protecting healthy cells against damage.
• Immune system protection. Various studies have shown that vitamin E supplementation, particularly in elderly patients, boosts immune system function. Older patients have demonstrated improved immune response, increased resistance to infections, and higher antibody production. Vitamin E has also been used with some success to slow disease progression in HIV-positive patients.
• Eye disease prevention. Clinical studies on vitamin E have shown that supplementation significantly reduces the risk for cataracts and for macular degeneration, particularly among women.
• Memory loss prevention. Vitamin E deficiency has been linked to poor performance on memory tests in some elderly individuals.
• Alzheimer’s disease (AD) treatment. In a study performed at Columbia University, researchers found that Alzheimer’s patients who took daily supplements of vitamin E maintained normal functioning longer than patients who took a placebo. In 2002, a group of Dutch epidemiologists reported on a much larger population based study conducted in the Netherlands between 1990 and 1993, with follow-up examinations in 1994 and 1999. The study confirmed the findings of the Columbia researchers, that high dietary intake of vitamin E lowers the risk of developing AD.
• Liver disease treatment. Vitamin E may protect the liver against disease.
• Diabetes treatment. Vitamin E may help diabetic patients process insulin more effectively. It has also been found to be effective in the treatment of diabetic neuropathy, a family of nerve disorders caused by diabetes. Vitamin E appears to reduce the symptoms of diabetic neuropathy and to improve the speed of transmission of nerve impulses.
• Pain relief. Vitamin E acts as both an anti-inflammatory and analgesic (or pain reliever). Studies have indicated it may be useful for treatment of arthritis pain in some individuals.
• Parkinson’s disease prevention. High doses of vitamin E intake was associated with a lowered risk of developing Parkinson’s disease in one 1997 Dutch study.
• Tardive dyskinesia treatment. Individuals who take neuroleptic drugs for schizophrenia or other disorders may suffer from a side effect known as tardive dyskinesia, in which they experience involuntary muscle contractions or twitches. Vitamin E supplementation may lessen or eliminate this side effect in some individuals.
• Porphyria treatment. Vitamin E has been found to be beneficial in treating patients with porphyria, a group of disorders characterized by abnormalities in the metabolism of blood pigments, by lowering the level of excretion of these blood pigments in the urine.

Other benefits of vitamin E are less clear cut, and have been called into question with conflicting study results or because of a lack of controlled studies to support them. These include:

fruit as source of vitamin E

• Heart disease prevention. A number of epidemiological studies have indicated that vitamin E may prevent heart disease by lowering total blood cholesterol levels and preventing oxidation of LDL cholesterol. However, a large, controlled study known as the Heart Outcomes Prevention Evaluation (HOPE) published in early 2000 indicates that vitamin E does not have any preventative effects against heart disease. The study followed 9,500 individuals who were considered to be at a high risk for heart disease. Half the individuals were randomly chosen to receive vitamin E supplementation, and the other half of the study population received a placebo. After five years, there was no measurable difference in heart attacks and heart disease between the two patient populations. Still, vitamin E may still hold some hope for heart disease prevention. It is possible that a longerterm study beyond the five years of the HOPE study may demonstrate some heart protective benefits of vitamin E consumption. It is also possible that while the high-risk patient population that was used for the HOPE study did not benefit from vitamin E, an average-risk patient population might still benefit from supplementation. It is also possible that vitamin E needs the presence of another vitamin or nutrient substance to protect against heart disease. Further large, controlled, and long-term clinical studies are necessary to answer these questions.
• Skin care. Vitamin E is thought to increase an individual’s tolerance to UV rays when taken as a supplement in conjunction with vitamin C. Vitamin E has also been touted as a treatment to promote faster healing of flesh wounds. While its anti-inflammatory and analgesic properties may have some benefits in reducing swelling and relieving discomfort in a wound, some dermatologists dispute the claims of faster healing, and there are no large controlled studies to support this claim.
• Hot flashes. In a small study conducted at the Mayo Clinic, researchers found that breast cancer survivors who suffered from hot flashes experienced a decrease in hot flashes after taking vitamin E supplementation.
• Muscle maintenance and repair. Recent research has demonstrated that the antioxidative properties of vitamin E may prevent damage to tissues caused by heavy endurance exercises. In addition, vitamin E supplementation given prior to surgical procedures on muscle and joint tissues has been shown to limit reperfusion injury (muscle damage that occurs when blood flow is stopped, and then started again to tissues or organs).
• Fertility. Vitamin E has been shown to improve sperm function in animal studies, and may have a similar effect in human males. Further studies are needed to establish the efficacy of vitamin E as a treatment for male infertility; as of 2002, its role in such treatment is still controversial.

Preparations

The U.S. recommended dietary allowance (RDA) of the alpha-tocopherol formulation of vitamin E is as follows:

• men: 10 mg or 15 IU
• women: 8 mg or 12 IU
• pregnant women: 10 mg or 15 IU
• lactating women: 12 mg or 18 IU

In April 2000, the National Academy of Sciences recommended changing the RDA for vitamin E to 22 international units (IUs), with an upper limit (UL), or maximum daily dose, of 1500 IUs. Daily values for the vitamin as recommended by the U.S. Food and Drug Administration, the values listed on food and beverage labeling, remain at 30 IUs for both men and women age four and older.

Many nuts, vegetable-based oils, fruits, and vegetables contain vitamin E. Foods rich in vitamin E include wheat germ oil (26.2 mg/tbsp), wheat germ cereal (19.5 mg/cup), peanuts (6.32 mg/half cup), soybeans (3.19 mg/cup), corn oil (2.87/tbsp), avocado (2.69 mg), and olive oil (1.68 mg/tbsp.). Grapes, peaches, broccoli, Brussels sprouts, eggs, tomatoes, and blackberries are also good sources of vitamin E. Fresh, raw foods contain the highest levels of the vitamin.

Both heat and light can reduce vitamin and mineral potency in fresh foods, so overcooking and improper storage should be avoided. Sliced and chopped foods have more of their surface exposed to light, therefore keeping vegetables and fruits whole may also help to maintain full vitamin potency.

For individuals considered at risk for vitamin E deficiency, or those with an inadequate dietary intake, vitamin E supplements are available in a variety of different forms, including pills, capsules, powders, and liquids for oral ingestion.

For topical use, vitamin E is available in ointments, creams, lotions, and oils. Vitamin E is also available commercially as one ingredient of a multivitamin formula.

The recommended daily dosage of vitamin E varies by individual need and by the amount of polyunsaturated fats an individual consumes.

The more polyunsaturated fats in the diet, the higher the recommended dose of vitamin E, because vitamin E helps to prevent the oxidizing effects of these fats. Because vitamin E is fat soluble, supplements should always be taken with food.

Supplements are also available in either natural or synthetic formulations. Natural forms are extracted from wheat germ oil and other vitamin E food sources, and synthetic forms are extracted from petroleum oils. Natural formulas can be identified by a d prefix on the name of the vitamin (i.e., d-alpha-tocopherol).

Precautions

Overdoses of vitamin E (over 536 mg) can cause nausea, diarrhea, headache, abdominal pain, bleeding, high blood pressure, fatigue, and weakened immune system function.

Patients with rheumatic heart disease, iron deficiency anemia, hypertension, or thyroid dysfunction should consult their healthcare provider before starting vitamin E supplementation, as vitamin E may have a negative impact on these conditions.

Side effects

Vitamin E is well-tolerated, and side effects are rare. However, in some individuals who are vitamin K deficient, vitamin E may increase the risk for hemorrhage or bleeding. In some cases, side effects may be decreased or eliminated by adjusting the dosage of vitamin E and vitamin K.

Although the reasons are not yet clear, high intake of vitamin E has been associated with a statistically significant increased risk of breast cancer in men.

Vitamin E ointments, oils, or creams may trigger an allergic reaction known as contact dermatitis. Individuals who are considering using topical vitamin E preparations for the first time, or who are switching the type of vitamin E product they use, should perform a skin patch test to check for skin sensitivity to the substance.

A small, dime sized drop of the product should be applied to a small patch of skin inside the elbow or wrist. The skin patch should be monitored for 24 hours to ensure no excessive redness, irritation, or rash occurs.

If a reaction does occur, it may be in response to other ingredients in the topical preparation, and the test can be repeated with a different vitamin E formulation. Individuals who experience a severe reaction to a skin patch test of vitamin E are advised not to use the product topically. A dermatologist or other healthcare professional may be able to recommend a suitable alternative.

Interactions

Individuals who take anticoagulant (blood thinning) or anticonvulsant medications should consult their healthcare provider before starting vitamin E supplementation. Vitamin E can alter the efficacy of these drugs.

It is important for persons taking supplemental vitamin E to tell their surgeon if they are scheduled for an operation. Vitamin E may interact with some of the medications given prior to or during surgery; it has also been shown to increase bleeding time if the patient is taking such other herbal preparations as feverfew or gingko biloba.

Non-heme, inorganic iron supplements destroy vitamin E, so individuals taking iron supplements should space out their doses (e.g., iron in the morning and vitamin E in the evening).

Large doses of vitamin A can decrease the absorption of vitamin E, so dosage adjustments may be necessary in individuals supplementing with both vitamins.

Alcohol and mineral oil can also reduce vitamin E absorption, and these substances should be avoided if possible in vitamin E deficient individuals.

Vitamin E source